doi: 10.1016/0005-2744(77)90059-6.
Spontaneous reactivation of acetylcholinesterase following organophosphate inhibition. I. An analysis of anomalous reactivation kinetics
- PMID: 19068
- DOI: 10.1016/0005-2744(77)90059-6
Item in Clipboard
Spontaneous reactivation of acetylcholinesterase following organophosphate inhibition. I. An analysis of anomalous reactivation kinetics
Biochim Biophys Acta.
.
Abstract
The first kinetic studies on the spontaneous reactivation of Sarin-inhibited acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) are reported. With increasing pH the extent of reactivation increases while the observed rate constant decreases. An analysis of the change in aging rate constant as a function of pH suggests that the aging of alkyl-alkoxy phosphonylated acetylcholinesterases is not solely acid catalyzed.
Similar articles
-
Spontaneous reactivation of acetylcholinesterase following organophosphate inhibition. II. Characterization of the reactivating components.Biochim Biophys Acta. 1977 Aug 11;483(2):320-30. doi: 10.1016/0005-2744(77)90060-2. Biochim Biophys Acta. 1977. PMID: 560865
-
Tacrine slows the rate of ageing of sarin-inhibited acetylcholinesterase.Neurosci Lett. 1989 May 22;100(1-3):227-30. doi: 10.1016/0304-3940(89)90689-7. Neurosci Lett. 1989. PMID: 2761772
-
Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches.Arch Toxicol. 2016 Mar;90(3):603-16. doi: 10.1007/s00204-015-1481-1. Epub 2015 Mar 6. Arch Toxicol. 2016. PMID: 25743373 Free PMC article.
-
The mechanism of ageing of phosphonylated acetylcholinesterase.Eur J Biochem. 1979 Oct 15;100(2):527-30. doi: 10.1111/j.1432-1033.1979.tb04198.x. Eur J Biochem. 1979. PMID: 510296
-
Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach.J Enzyme Inhib Med Chem. 2011 Jun;26(3):303-8. doi: 10.3109/14756366.2010.504673. Epub 2010 Aug 31. J Enzyme Inhib Med Chem. 2011. PMID: 20807085 Review.
Cited by
-
Novel Organophosphate Ligand O-(2-Fluoroethyl)-O-(p-Nitrophenyl)Methylphosphonate: Synthesis, Hydrolytic Stability and Analysis of the Inhibition and Reactivation of Cholinesterases.Chem Res Toxicol. 2016 Nov 21;29(11):1810-1817. doi: 10.1021/acs.chemrestox.6b00160. Epub 2016 Oct 17. Chem Res Toxicol. 2016. PMID: 27551891 Free PMC article.
-
Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.PLoS One. 2011 Mar 18;6(3):e17441. doi: 10.1371/journal.pone.0017441. PLoS One. 2011. PMID: 21445272 Free PMC article.
-
Engineering Dynamic Surface Peptide Networks on ButyrylcholinesteraseG117H for Enhanced Organophosphosphorus Anticholinesterase Catalysis.Chem Res Toxicol. 2019 Sep 16;32(9):1801-1810. doi: 10.1021/acs.chemrestox.9b00146. Epub 2019 Aug 28. Chem Res Toxicol. 2019. PMID: 31411024 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
