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Comment
. 2008 Dec 12;135(6):1004-6.
doi: 10.1016/j.cell.2008.11.029.

Bcl-2 proteins and apoptosis: choose your partner

Gordon C Shore  1 , Mai Nguyen
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Bcl-2 proteins and apoptosis: choose your partner

Gordon C Shore et al. Cell. .
Free article

Abstract

The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. (2008) now describe the reconstitution and regulation in liposomes of tBid-mediated membrane penetration and oligomerization of Bax. These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis.

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