Review
doi: 10.1016/j.cell.2008.11.024.
Collateral damage from antigen receptor gene diversification
Affiliations
- PMID: 19070571
- DOI: 10.1016/j.cell.2008.11.024
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Review
Collateral damage from antigen receptor gene diversification
Cell.
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Free article
Abstract
Chromosomal translocations that juxtapose antigen receptor genes and oncogenes are frequently associated with lymphoid malignancies. In this issue, Robbiani et al. (2008) show that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and Tsai et al. (2008) propose that AID and the recombinase-activating gene (RAG) endonuclease may collaborate to generate off-target DSBs.
Comment on
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AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.Cell. 2008 Dec 12;135(6):1028-38. doi: 10.1016/j.cell.2008.09.062. Cell. 2008. PMID: 19070574 Free PMC article.
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Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity.Cell. 2008 Dec 12;135(6):1130-42. doi: 10.1016/j.cell.2008.10.035. Cell. 2008. PMID: 19070581 Free PMC article.
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