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Review
. 2008 Dec 12;135(6):1013-6.
doi: 10.1016/j.cell.2008.11.026.

HMGA2, microRNAs, and stem cell aging

Scott M Hammond  1 , Norman E Sharpless
Affiliations
Review

HMGA2, microRNAs, and stem cell aging

Scott M Hammond et al. Cell. .

Abstract

Mammalian aging results from a replicative decline in the function of somatic stem cells and other self-renewing cells. Recent studies (Monzen et al., 2008; Nishino et al., 2008; Sanna et al., 2008; Weedon et al., 2008) link a chromatin-associated protein, HMGA2, to development, height, and mouse stem cell aging during late fetal development and young adulthood.

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Figures

Figure 1
Figure 1. HMGA2 and let-7 in Mammalian Development
MicroRNAs (miRNAs) are generated as long primary transcripts (pri-miRNAs) that are processed by the Drosha/DGC8 complex into pre-miRNAs. Further processing by the endoribonuclease Dicer produces the 22 nucleotide mature miRNAs. Production of the let-7 miRNA during development is regulated by the RNA binding protein Lin-28. Mature let-7 targets multiple genes, including HMGA2. This architectural transcription factor represses INK4a/ARF expression, possibly through the repression of JunB.
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Comment on

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