A synthetic lectin for O-linked beta-N-acetylglucosamine
- PMID: 19072969
- PMCID: PMC2835298
- DOI: 10.1002/anie.200804905
A synthetic lectin for O-linked beta-N-acetylglucosamine
Abstract
Changing employment: Receptor 1 binds beta-N-acetylglucosaminyl (beta-GlcNAc) up to 100 times more strongly than it does glucose. This synthetic lectin shows affinities similar to wheat germ agglutinin (WGA), a natural lectin used to bind GlcNAc. Remarkably, 1 is more selective than WGA. It favors especially the glycoside unit in glycopeptide 2, a model of the serine-O-GlcNAc posttranslational protein modification.
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Comment in
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Synthetic lectins.Angew Chem Int Ed Engl. 2009;48(10):1722-5. doi: 10.1002/anie.200805497. Angew Chem Int Ed Engl. 2009. PMID: 19115356
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