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Comparative Study
. 2009 Mar 18;369(1-2):47-52.
doi: 10.1016/j.ijpharm.2008.10.038. Epub 2008 Nov 27.

Use of (1)H NMR to facilitate solubility measurement for drug discovery compounds

Melissa Lin  1 , Marc Tesconi, Mark Tischler
Affiliations
Comparative Study

Use of (1)H NMR to facilitate solubility measurement for drug discovery compounds

Melissa Lin et al. Int J Pharm. .

Abstract

The use of (1)H NMR experiments to determine the solubility of potential drug candidates using a panel of solubilizing agents is proposed as an alternative to an HPLC-UV method. The advantages of using this approach will be discussed and results comparing the two methodologies will be presented. This effort highlights the importance of a simple method for determining a suitable formulation for discovery compounds for studies using a minimal amount of material in support of early in vivo studies.

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