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Comment
. 2008 Dec 16;105(50):19565-6.
doi: 10.1073/pnas.0810654106. Epub 2008 Dec 10.

Opening and closing the metabolite gate

Susanna Törnroth-Horsefield  1 , Richard Neutze
Affiliations
Comment

Opening and closing the metabolite gate

Susanna Törnroth-Horsefield et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Conformational flexibility within the N-terminal region of VDAC and its putative role in gating. (A) Diagram and surface representation of the X-ray structure of mVDAC1 to 2.3-Å resolution (8). (B) Proposed model for the closed conformation (8). A space-filling model for ATP indicates its size relative to the pore diameter. A path through VDAC that is sufficiently large for ATP to pass becomes partially occluded in the putative closed conformation.
See this image and copyright information in PMC

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