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Comment
. 2008 Dec 16;105(50):19567-8.
doi: 10.1073/pnas.0811124106. Epub 2008 Dec 10.

Sleep, arousal, and rhythms in flies

Ezio Rosato  1 , Charalambos P Kyriacou
Affiliations
Comment

Sleep, arousal, and rhythms in flies

Ezio Rosato et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Locomotor activity in flies is mediated by the circadian clock, sleep homeostasis, and arousal. (Left) PDF-positive l-LNvs (colored yellow when expressing NaChBac) and their projections to the medulla (to their left) and contralaterally (to their right). (Magnification: 400×). The dorsal projection originates from the s-LNvs (intensively stained cells immediately below the l-LNvs but not individually distinguishable here). (Top) Flies overexpressing NaChBac (NB, yellow) become more active and sleep less at night. This observation is reflected in the elevated nocturnal activity levels in Center, which shows average daily locomotion (for several flies) during the light–dark cycle (open and filled bars, respectively) and is represented in Right by the high levels of arousal (large yellow font), high levels of nocturnal activity (large red font), and lower levels of sleep (smaller blue font). (Middle) Wild-type flies are generally more active during the day than at night but they also take a nap in the middle of the day, so their levels of arousal sleep, and activity are more balanced (fonts in Right more similar in size). (Bottom) Flies whose l-LNvs have been genetically ablated have low daytime locomotor activity levels and more daytime sleep (low arousal), hence a relative change in corresponding font sizes in Right.
See this image and copyright information in PMC

Comment on

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