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. 2009 Mar;32(3):424-6.
doi: 10.2337/dc08-1265. Epub 2008 Dec 15.

Lower serum creatinine is a new risk factor of type 2 diabetes: the Kansai healthcare study

Nobuko Harita  1 , Tomoshige Hayashi, Kyoko Kogawa Sato, Yoshiko Nakamura, Takeshi Yoneda, Ginji Endo, Hiroshi Kambe
Affiliations

Lower serum creatinine is a new risk factor of type 2 diabetes: the Kansai healthcare study

Nobuko Harita et al. Diabetes Care. 2009 Mar.

Abstract

Objective: Because skeletal muscle is one of the target tissues for insulin, skeletal muscle mass might be associated with type 2 diabetes. Serum creatinine is a possible surrogate marker of skeletal muscle mass. The purpose of this study was to determine whether serum creatinine level is associated with type 2 diabetes.

Research design and methods: The study participants were nondiabetic Japanese men (n = 8,570) aged 40-55 years at entry. Type 2 diabetes was diagnosed if fasting plasma glucose was >or=126 mg/dl or if participants were taking oral hypoglycemic medication or insulin.

Results: During the 4-year follow-up period, 877 men developed type 2 diabetes. Lower serum creatinine was associated with an increased risk of type 2 diabetes. The multiple-adjusted odds ratio for those who had serum creatinine levels between 0.40 and 0.60 mg/dl was 1.91 (95% CI 1.44-2.54) compared with those who had levels between 0.71 and 0.80 mg/dl.

Conclusions: Lower serum creatinine increased the risk of type 2 diabetes.

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