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Editorial
. 2009 Jan;40(1):1-3.
doi: 10.1165/rcmb.2008-0011ED.

Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap

Anne-Karina Perl, Liqian Zhang, Jeffrey A Whitsett
Editorial

Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap

Anne-Karina Perl et al. Am J Respir Cell Mol Biol. 2009 Jan.
No abstract available

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Figures

<b>Figure 1.</b>
Figure 1.
Immunohistochemistry for Cre protein expression is shown after 48 hours of doxycycline treatment of adult transgenic mice. SP-C-rtTA (line 1) and SP-C-rtTA (line 2) otet-Cre mice express Cre in conducting airways (open arrowheads) and alveolar type II cells (arrowheads in A and B). (C) CCSP-rtTA (line 1) mice express Cre at high levels in a subset of nonciliated bronchiolar and alveolar cells. (D) With the CCSP-rtTA (line 2) mice, Cre was readily detected at high levels in most non-ciliated bronchiolar epithelial cells and staining was rarely seen in alveolar type II cells.
See this image and copyright information in PMC

References

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