Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Dec 22;205(13):2953-7.
doi: 10.1084/jem.20082622.

Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

Pierre Bougnères  1 , Alain-Jacques Valleron
Affiliations
Comment

Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

Pierre Bougnères et al. J Exp Med. .

Abstract

A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and beta cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality.

PubMed Disclaimer

Comment on

References

    1. Bottazzo, G.F., A. Florin-Christensen, and D. Doniach. 1974. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. ii:1280–1283. - PubMed
    1. Nerup, J., P. Platz, O.O. Andersen, M. Christy, J. Lyngsoe, J.E. Poulsen, L.P. Ryder, L.S. Nielsen, M. Thomsen, and A. Svejgaard. 1974. HL-A antigens and diabetes mellitus. Lancet. ii:864–866. - PubMed
    1. Benacerraf, B., and H.O. McDevitt. 1972. Histocompatibility-linked immune response genes. Science. 175:273–279. - PubMed
    1. Srikanta, S., O.P. Ganda, G.S. Eisenbarth, and J.S. Soeldner. 1983. Islet-cell antibodies and beta-cell function in monozygotic triplets and twins initially discordant for Type I diabetes mellitus. N. Engl. J. Med. 308:322–325. - PubMed
    1. Ziegler, A.G., M. Hummel, M. Schenker, and E. Bonifacio. 1999. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes. 48:460–468. - PubMed

Publication types

MeSH terms