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. 2009 Feb;8(1):73-5.
doi: 10.1111/j.1474-9726.2008.00449.x. Epub 2008 Dec 11.

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Viviana I Pérez  1 , Holly Van Remmen, Alex Bokov, Charles J Epstein, Jan Vijg, Arlan Richardson
Affiliations

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Viviana I Pérez et al. Aging Cell. 2009 Feb.

Abstract

We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.

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Figures

Fig. 1
Fig. 1
Lifespans of male transgenic mice overexpressing various antioxidant enzymes. Survival studies were conducted as described by Ran et al. (2007), and all mice were on the C57BL/6J background. The mice were housed four animals per cage starting at 2 months of age and fed a commercial mouse chow (Teklad Diet LM485) ad libitum. The survival of the WT cohort is presented in each of the graphs. The number of animals and the survival data are given in Table 1.
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