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. 2008 Dec;29(6):501-7.
doi: 10.1097/DBP.0b013e318190b290.

The longitudinal course of comorbid oppositional defiant disorder in girls with attention-deficit/hyperactivity disorder: findings from a controlled 5-year prospective longitudinal follow-up study

Joseph Biederman  1 , Carter R Petty, Michael C Monuteaux, Eric Mick, Tiffany Parcell, Diana Westerberg, Stephen V Faraone
Affiliations

The longitudinal course of comorbid oppositional defiant disorder in girls with attention-deficit/hyperactivity disorder: findings from a controlled 5-year prospective longitudinal follow-up study

Joseph Biederman et al. J Dev Behav Pediatr. 2008 Dec.

Abstract

Objective: A better understanding of the long-term scope and impact of the comorbidity with oppositional defiant disorder (ODD) in girls with attention-deficit/hyperactivity disorder (ADHD) has important clinical and public health implications. However, most of the available information on the subject derives from predominantly male samples. This study evaluated the longitudinal course and impact of comorbid ODD in a large sample of girls with ADHD.

Methods: Subjects were pediatrically and psychiatrically referred girls with and without ADHD assessed blindly at baseline (mean age = 11.6 years), and 5 years later (mean age = 16.6 years) by mid to late adolescence. The subjects' diagnostic status of ADHD with and without comorbid ODD at baseline was used to define three groups (controls [N = 107], ADHD [N = 77], ADHD + ODD [N = 37]). Outcomes were examined using logistic regression (for binary outcomes) and linear regression (for continuous outcomes).

Results: Compared with girls who had ADHD only, those with ADHD + ODD at baseline had a significantly increased risk for ODD and major depression at follow-up. Both groups of girls with ADHD had an increased risk for conduct disorder and bipolar disorder at follow-up.

Conclusions: These longitudinal findings in girls with ADHD support and extend previously reported findings in boys indicating that ODD heralds a compromised outcome for girls with ADHD in adolescence.

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Figures

Figure 1
Figure 1
Diagnoses at five-year follow-up in girls with ADHD and ODD, with ADHD without ODD, and controls. A=vs. Controls, B=vs. ADHD; *p≤0.05, **p≤0.01, ***p≤0.001
Figure 2
Figure 2
Child Behavior Checklist profiles in girls with ADHD and ODD, ADHD without ODD, and controls.
Figure 3
Figure 3
School outcomes at five-year follow-up in girls with ADHD and ODD, with ADHD without ODD, and controls. A=vs. Controls, B=vs. ADHD; *p≤0.05, **p≤0.01, ***p≤0.001
See this image and copyright information in PMC

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