Anesthesia in patients with neuromuscular disorders

Abstract

Neuromuscular disorders (NMDs) are a heterogeneous group of neurological and muscular diseases. Patients present with typical features such as wasting and weakness of skeletal muscles. However, despite these common clinical signs, underlying etiologies are nearly as multifaceted as the number of the diseases. For the anesthesiologist, it is very important to know the origin of a particular disease to select an appropriate anesthetic technique. Patients with NMDs are markedly sensitive to several anesthetics. Many reported anesthesia-related complications were caused by the administration of drugs like depolarizing and non-depolarizing muscle relaxants, volatile anesthetics, or respiratory and cardiovascular depressant agents.