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Review
. 2009 Jan;34(1):248-9.
doi: 10.1038/npp.2008.156.

Promise of mGluR2/3 activators in psychiatry

P Jeffrey Conn  1 , Carrie K Jones
Affiliations
Review

Promise of mGluR2/3 activators in psychiatry

P Jeffrey Conn et al. Neuropsychopharmacology. 2009 Jan.
No abstract available

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References

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    1. Galici R, Jones CK, Hemstapat K, Nong Y, Eche- mendia NG, Williams LC, et al. Biphenyl- indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther. 2006;318:173–185. - PubMed
    1. Johnson MP, Baez M, Jagdmann GE, Jr, Britton TC, Large TH, Callagaro DO, et al. Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine. J Med Chem. 2003;46:3189–3192. - PubMed
    1. Patil ST, Zhang L, Martenyi F, Lowe SL, Jackson KA, Andreev BV, et al. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial. Nat Med. 2007;13:1102–1107. - PubMed
    1. Schoepp DD, Marek GJ. Preclinical pharmacology of mGlu2/3 receptor agonists: novel agents for schizophrenia? Curr Drug Target CNS Neurol Disord. 2002;1:215–225. - PubMed

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