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. 2009 Jan;16(1):94-5.
doi: 10.1038/nsmb.1523. Epub 2008 Dec 14.

Structure of the motor subunit of type I restriction-modification complex EcoR124I

Mikalai Lapkouski  1 , Santosh Panjikar, Pavel Janscak, Ivana Kuta Smatanova, Jannette Carey, Rüdiger Ettrich, Eva Csefalvay
Affiliations

Structure of the motor subunit of type I restriction-modification complex EcoR124I

Mikalai Lapkouski et al. Nat Struct Mol Biol. 2009 Jan.

Abstract

Type I restriction-modification enzymes act as conventional adenine methylases on hemimethylated DNAs, but unmethylated recognition targets induce them to translocate thousands of base pairs before cleaving distant sites nonspecifically. The first crystal structure of a type I motor subunit responsible for translocation and cleavage suggests how the pentameric translocating complex is assembled and provides a structural framework for translocation of duplex DNA by RecA-like ATPase motors.

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