Decision by committee: new light on the CD4/CD8-lineage choice

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Comment

Ellen V Rothenberg. Immunol Cell Biol. 2009 Feb.

. 2009 Feb;87(2):109-12.

doi: 10.1038/icb.2008.100. Epub 2008 Dec 16.

No abstract available

Comment on

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells.
Wang L, Wildt KF, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, Paul WE, Fowlkes BJ, Bosselut R. Wang L, et al. Nat Immunol. 2008 Oct;9(10):1122-30. doi: 10.1038/ni.1647. Epub 2008 Sep 7. Nat Immunol. 2008. PMID: 18776904 Free PMC article.
ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage.
Egawa T, Littman DR. Egawa T, et al. Nat Immunol. 2008 Oct;9(10):1131-9. doi: 10.1038/ni.1652. Epub 2008 Sep 7. Nat Immunol. 2008. PMID: 18776905 Free PMC article.
Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate.
Muroi S, Naoe Y, Miyamoto C, Akiyama K, Ikawa T, Masuda K, Kawamoto H, Taniuchi I. Muroi S, et al. Nat Immunol. 2008 Oct;9(10):1113-21. doi: 10.1038/ni.1650. Epub 2008 Sep 7. Nat Immunol. 2008. PMID: 18776907