[Kinetics of cell proliferation and growth of transplanted hepatoma in mice]

Abstract

The authors compared the parameters of the growth and kinetics of the cell proliferation of five strains of transplantable mice hepatoma. By means of autoradiography and 3H-thymidine the curves of labeled mitoses and these of persistently labeled cells were obtained and analysed. Of all the mitotic cycle parameters: the time of G2 period and duration of phase S are mostly constant and not related with the rate of tumors growth. Hepatoma 46 is characterized by an extremely low intensity of cell production in relatively low their death rate. On the contrary, in hepatoma 48 possessing the same rate of growth the cell production was much more intensive, the rate of cell death being very high.