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. 2008 Dec;15(6):279-85.
doi: 10.3747/co.v15i6.378.

The Colon Health and Life-Long Exercise Change trial: a randomized trial of the National Cancer Institute of Canada Clinical Trials Group

K S Courneya  1 , C M Booth, S Gill, P O'Brien, J Vardy, C M Friedenreich, H J Au, M D Brundage, D Tu, H Dhillon, R M Meyer
Affiliations

The Colon Health and Life-Long Exercise Change trial: a randomized trial of the National Cancer Institute of Canada Clinical Trials Group

K S Courneya et al. Curr Oncol. 2008 Dec.

Abstract

Background: Observational studies indicate that physical activity (PA) is strongly associated with improved disease outcomes in colon cancer survivors, but a randomized controlled trial is needed to determine whether the association is causal and whether new policies to promote exercise are justified.

Purpose: The co.21 Colon Health and Life-Long Exercise Change (challenge) trial undertaken by the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) is designed to determine the effects of a structured pa intervention on outcomes for survivors of high-risk stage II or III colon cancer who have completed adjuvant therapy within the previous 2-6 months.

Methods: Trial participants (n = 962) will be stratified by centre, disease stage, body mass index, and performance status, and will be randomly assigned to a structured pa intervention or to general health education materials. The pa intervention will consist of a behavioural support program and supervised pa sessions delivered over a 3-year period, beginning with regular face-to-face sessions and tapering to less frequent face-to-face or telephone sessions. The primary endpoint is disease-free survival. Important secondary endpoints include multiple patient-reported outcomes, objective physical functioning, biologic correlative markers, and an economic analysis.

Summary: Cancer survivors and cancer care professionals are interested in the potential role of PA to improve multiple disease-related outcomes, but a randomized controlled trial is needed to provide compelling evidence to justify changes in health care policies and practice.

Keywords: Behavioural oncology; cancer survivor; disease-free survival; exercise; lifestyle; physical activity; quality of life; survivorship.

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Figures

FIGURE 1
FIGURE 1
Flow of participants through the Colon Health and Life-Long Exercise Change (CHALLENGE) trial.
See this image and copyright information in PMC

References

    1. nih Consensus Conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA. 1990;264:1444–50. - PubMed
    1. André T, Boni C, Mounedji–Boudiaf L, et al. on behalf of the mosaic Investigators. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 2004;350:2343–51. - PubMed
    1. Meyerhardt JA, Heseltine D, Niedzwiecki D, et al. Impact of physical activity on cancer recurrence and survival in patients with stage iii colon cancer: findings from calgb 89803. J Clin Oncol. 2006;24:3535–41. - PubMed
    1. Meyerhardt JA, Giovannucci EL, Holmes MD, et al. Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol. 2006;24:3527–34. - PubMed
    1. McTiernan A. Mechanisms linking physical activity with cancer. Nat Rev Cancer. 2008;8:205–11. - PubMed

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