[Familiar gastric cancer: case report and systematic review of the Chinese literature]

Abstract

Objective: To investigate the clinicopathologic characteristics of familiar gastric cancer (FGC) in Chinese.

Methods: A family with FGC was screened. China National Knowledge Infrastructure was retrieved, and fifteen families with FGC were collected. Systematic literature review was carried out on these sixteen families.

Results: There were 63 cases of FGC in these 16 families, 38 males and 25 females, aged 54 (30 - 72). The mean age of the parental patients was 61, older than that of the filial patients (43 years, Z = 3.494, P < 0.01). There was a correlation between the ages of sibling patients (r(s) = 0.664, P < 0.01). Among the 44 cases with clearly described tumor location, the tumor was located in the gastric antrum in 21 patients (47.7%). Among the 8 families with complete records of tumor location, 4 families showed consistent tumor location. Accompanying other malignant tumors were seen in 7 families, 5 being tumors in the alimentary canal.

Conclusion: The onset age of filial patients with FGC is younger than that of the parental patients in Chinese. The onset ages of the sibling cases are significantly correlated. In a specific family the tumor is nearly located at the same places. And most of tumors are located in gastric antrum.Most of the accompanying tumors are alimentary canal tumors.