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. 1991 Jun;5(3):215-9.
doi: 10.1016/0890-8508(91)90043-j.

Differentiation of Mycobacterium tuberculosis and Mycobacterium bovis BCG by a polymerase chain reaction assay

B B Plikaytis  1 , K D Eisenach, J T Crawford, T M Shinnick
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Differentiation of Mycobacterium tuberculosis and Mycobacterium bovis BCG by a polymerase chain reaction assay

B B Plikaytis et al. Mol Cell Probes. 1991 Jun.

Abstract

Mycobacterium tuberculosis and Mycobacterium bovis are closely related species which carry different numbers of the repetitive DNA element IS6110. A polymerase chain reaction assay was developed to assess the copy number of IS6110 in a strain and thereby differentiate these two important human pathogens.

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