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Review
. 2009 Jan;11(1):73-80.
doi: 10.1007/s11912-009-0012-8.

Insights into the biology of primary central nervous system lymphoma

Maciej M Mrugala  1 , James L Rubenstein, Maurilio Ponzoni, Tracy T Batchelor
Affiliations
Review

Insights into the biology of primary central nervous system lymphoma

Maciej M Mrugala et al. Curr Oncol Rep. 2009 Jan.

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare variant of non-Hodgkin lymphoma that is confined to the central nervous system. Biologic studies of PCNSL are challenging to conduct because the disease is rare and available tissue material is sparse. However, in recent years there has been progress in the understanding of PCNSL biology, largely as the result of multicenter studies using modern molecular techniques. Recent studies may improve insight into the pathogenesis of PCNSL and increase the chances of identifying prognostic factors and novel therapeutic targets. This review discusses recent advances in PCNSL biology, including immunologic and genetic risk factors, and focuses on the molecular alterations important in central nervous system lymphomagenesis.

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Figures

Figure 1
Figure 1
Model for diffuse large B-cell lymphoma pathogenesis. Only the most common genetic lesions and their frequencies are shown. Genetic lesions more specific for primary central nervous system lymphoma (PCNSL) include somatic hypermutations as well as chromosomal translocations, especially those involving the IgH and BCL-6 genes. TP53 mutations are rare in PCNSL. (Adapted from Lossos [13].)
See this image and copyright information in PMC

References

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