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Review
. 2008 Dec 10;60(5):731-2.
doi: 10.1016/j.neuron.2008.11.020.

A sequel to the tale of p25/Cdk5 in neurodegeneration

Burcin Ikiz  1 , Serge Przedborski
Affiliations
Free article
Review

A sequel to the tale of p25/Cdk5 in neurodegeneration

Burcin Ikiz et al. Neuron. .
Free article

Abstract

p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show that cdk5 inactivates HDAC-1, leading to cell cycle deregulation and DNA damage accumulation. This study provides further insights into the function of p25/Cdk5 in neurons and points to HDAC-1 as a target for therapeutic interventions.

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  • Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.
    Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH. Kim D, et al. Neuron. 2008 Dec 10;60(5):803-17. doi: 10.1016/j.neuron.2008.10.015. Neuron. 2008. PMID: 19081376 Free PMC article.

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