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. 2009 Jan 7;7(1):30-3.
doi: 10.1039/b813252f. Epub 2008 Oct 30.

Cleavage of RNA oligonucleotides by aminoglycosides

Matthew J Belousoff  1 , Bim Graham, Leone Spiccia, Yitzhak Tor
Affiliations

Cleavage of RNA oligonucleotides by aminoglycosides

Matthew J Belousoff et al. Org Biomol Chem. .

Abstract

A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.

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