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. 2009 Jan 7:(1):80-2.
doi: 10.1039/b816861j. Epub 2008 Nov 12.

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition

Sebastian Müller  1 , G Dan Pantoş, Raphaël Rodriguez, Shankar Balasubramanian
Affiliations

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition

Sebastian Müller et al. Chem Commun (Camb). .

Abstract

Differential recognition of diverse G-quadruplex structures can be achieved by controlling the folding of a small molecule.

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Figures

Fig. 1
Fig. 1
Molecular structure of the ligands.
Fig. 2
Fig. 2
Coiled conformation adopted by 1a.
Fig. 3
Fig. 3
Twisted conformation adopted by 2a. The nOe cross peaks are indicated with arrows.
Fig. 4
Fig. 4
W-Shaped conformation of 3a. The nOe cross peaks are indicated with arrows.
Fig. 5
Fig. 5
ΔTm at different concentrations of ligand 1a: (pink) K-ras, (red) c-kit1, (yellow) h-Telo, (green) c-kit2, (blue) c-myc, (black) ds-DNA.
Fig. 6
Fig. 6
ΔTm at different concentrations of ligand 2a: (pink) K-ras, (red) c-kit1, (yellow) h-Telo, (green) c-kit2, (blue) c-myc, (black) ds-DNA.
Fig. 7
Fig. 7
ΔTm at different concentrations of ligand 3a: (pink) K-ras, (red) c-kit1, (yellow) h-Telo, (green) c-kit2, (blue) c-myc, (black) ds-DNA.
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References

    1. Rankin S, Reszka AP, Huppert J, Zloh M, Parkinson GN, Todd AK, Ladame S, Balasubramanian S, Neidle S. J. Am. Chem. Soc. 2005;127:10584. - PMC - PubMed
    2. Fernando H, Reszka AP, Huppert J, Ladame S, Rankin S, Venkitaraman AR, Neidle S, Balasubramanian S. Biochemistry. 2006;45:7854. - PMC - PubMed
    1. Siddiqui-Jain A, Grand CL, Bearss DJ, Hurley LH. Proc. Natl. Acad. Sci. U. S. A. 2002;99:11593. - PMC - PubMed
    1. Cogoi S, Xodo LE. Nucleic Acids Res. 2006;34:2536. - PMC - PubMed
    1. Zahler AM, Williamson JR, Cech TR, Prescott DM. Nature. 1991;350:718. - PubMed
    1. Gomez D, O’Donohue M-F, Wenner T, Douarre C, Macadré J, Koebel P, Giraud-Panis M-J, Kaplan H, Kolkes A, Shin-ya K, Riou J-F. Cancer Res. 2006;66:6908. - PubMed
    2. Bejugam M, Sewitz S, Shirude PS, Rodriguez R, Shahid R, Balasubramanian S. J. Am. Chem. Soc. 2007;129:12926. - PMC - PubMed
    3. Ou T-M, Lu Y-J, Zhang C, Huang Z-S, Wang X-D, Tan J-H, Chen Y, Ma D-L, Wong K-Y, Tang JC-O, Chan AS-C, Gu L-Q. J. Med. Chem. 2007;50:1465. - PubMed
    4. Rodriguez R, Müller S, Yeoman JA, Trentesaux C, Riou J-F, Balasubramanian S. J. Am. Chem. Soc. 2008 DOI: 10.1021/ja805615w. - PMC - PubMed

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