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. 2009 Jan 7:(1):80-2.
doi: 10.1039/b816861j. Epub 2008 Nov 12.

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition

Sebastian Müller  1 , G Dan Pantoş, Raphaël Rodriguez, Shankar Balasubramanian
Affiliations

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition

Sebastian Müller et al. Chem Commun (Camb). .

Abstract

Differential recognition of diverse G-quadruplex structures can be achieved by controlling the folding of a small molecule.

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Figures

Fig. 1
Fig. 1
Molecular structure of the ligands.
Fig. 2
Fig. 2
Coiled conformation adopted by 1a.
Fig. 3
Fig. 3
Twisted conformation adopted by 2a. The nOe cross peaks are indicated with arrows.
Fig. 4
Fig. 4
W-Shaped conformation of 3a. The nOe cross peaks are indicated with arrows.
Fig. 5
Fig. 5
ΔTm at different concentrations of ligand 1a: (pink) K-ras, (red) c-kit1, (yellow) h-Telo, (green) c-kit2, (blue) c-myc, (black) ds-DNA.
Fig. 6
Fig. 6
ΔTm at different concentrations of ligand 2a: (pink) K-ras, (red) c-kit1, (yellow) h-Telo, (green) c-kit2, (blue) c-myc, (black) ds-DNA.
Fig. 7
Fig. 7
ΔTm at different concentrations of ligand 3a: (pink) K-ras, (red) c-kit1, (yellow) h-Telo, (green) c-kit2, (blue) c-myc, (black) ds-DNA.
See this image and copyright information in PMC

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