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. 2008 Dec 14:(46):6197-9.
doi: 10.1039/b813428f. Epub 2008 Oct 24.

An outstanding palladium system containing a C2-symmetrical phosphite ligand for enantioselective allylic substitution processes

Angelica Balanta Castillo  1 , Isabelle Favier, Emmanuelle Teuma, Sergio Castillón, Cyril Godard, Ali Aghmiz, Carmen Claver, Montserrat Gómez
Affiliations

An outstanding palladium system containing a C2-symmetrical phosphite ligand for enantioselective allylic substitution processes

Angelica Balanta Castillo et al. Chem Commun (Camb). .

Abstract

The use of efficient Pd systems bearing C(2)-symmetric chiral diphosphite ligands derived from carbohydrates in asymmetric allylic substitution reactions is described here, reaching TOFs > 22 000 h(-1) in allylic alkylation and ca. 400 h(-1) in allylic amination, giving excellent enantioselectivities (ee > 99%) and kinetic resolution of the racemic substrate.

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