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Review
. 2009 Jan;58(1):66-80.
doi: 10.1007/s00101-008-1455-2.

[Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium]

[Article in German]
H J Sparr  1 , L H Booij, T Fuchs-Buder
Affiliations
Review

[Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium]

[Article in German]
H J Sparr et al. Anaesthesist. 2009 Jan.

Abstract

Up to now only acetylcholine esterase inhibitors, such as neostigmine, were available as antagonists of residual neuromuscular blocks. Sugammadex is a modified gamma-cyclodextrin that binds rocuronium and chemically similar aminosteroidal muscle relaxants, such as vecuronium. The underlying mechanism of action is new and differs completely from that of acetylcholine esterase inhibitors. This review summarizes data published so far within the framework of the licensing procedure about the efficacy, safety and side-effects of sugammadex and presents potential new anesthesiological concepts using this compound.

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References

    1. Anesthesiology. 2002 Nov;97(5):1082-92 - PubMed
    1. J Pharmacokinet Pharmacodyn. 2007 Dec;34(6):771-88 - PubMed
    1. Anesthesiology. 2003 Sep;99(3):632-7; discussion 6A - PubMed
    1. Rapid Commun Mass Spectrom. 2002;16(20):1946-52 - PubMed
    1. Br J Anaesth. 2000 Nov;85(5):717-23 - PubMed

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