SURA2 targeting for cardioprotection?

Abstract

SUR2A is an ATP-binding protein known to serve as a regulatory subunit of metabolic-sensing, cardioprotective sarcolemmal ATP-sensitive K(+) (K(ATP)) channels. It has been recently found that a moderate increase in expression of SUR2A protects the heart against different types of metabolic stresses, including ischaemia/reperfusion and hypoxia. Although the sarcolemmal K(ATP) channel is a multiprotein complex composed of many proteins in vivo, it seems that an increase in SUR2A levels is sufficient to increase the number of sarcolemmal K(ATP) channels. This effect of SUR2A could be due to SUR2A being the rate-limiting factor in generating fully composed sarcolemmal K(ATP) channels. An increased number of sarcolemmal K(ATP) channels seems to protect the heart by regulating action membrane potential, inhibiting Ca(2+) influx and preventing Ca(2+) overload, although an additional yet to be recognised mechanism independent of K(ATP) channels activity cannot be excluded.