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. 2008 Dec 14;14(46):7107-11.
doi: 10.3748/wjg.14.7107.

Identification of human papillomavirus in esophageal squamous papillomas

Olga-L Bohn  1 , Leticia Navarro, Jesus Saldivar, Sergio Sanchez-Sosa
Affiliations

Identification of human papillomavirus in esophageal squamous papillomas

Olga-L Bohn et al. World J Gastroenterol. .

Abstract

Aim: To investigate the presence of human papillomavirus (HPV) in esophageal squamous papilloma (ESP) and determine p16, p53 and Ki67 expression in a Mexican cohort.

Methods: Nineteen cases diagnosed as ESP, corresponding to 18 patients were reviewed; nineteen cases of normal esophageal mucosa were used as negative controls. HPV detection was performed by amplified chromogenic in situ hybridization (ACISH) using a wide spectrum-cocktail probe and PCR.

Results: The average age at presentation was 46.3 years (range 28-72 years). Patients included four (22.22%) males and 14 (77.77%) females. The most frequent location was upper third (11 cases), followed by middle third (3 cases) and unknown site (5 cases). Immunohistochemistry (IHC) revealed basal and focal p53 expression in 17 cases (89%); p16 was expressed in eight cases (42.10%) and the Ki67 index ranged from 10% to 30%. HPV was detected in 14 out of 16 cases (87.5%) by ACISH: Twelve showed diffuse nuclear patterns and two showed granular patterns. HPV DNA was identified by PCR in 12 out of 14 cases (85.7%). Low-risk HPV types were detected in the most of the cases.

Conclusion: This study provides identification of HPV infection in almost 80% of ESP using either ACISH or PCR; overall, all of these lesions show low expression of cell-cycle markers. We suggest ACISH as an alternative diagnostic tool for HPV detection in ESP.

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Figures

Figure 1
Figure 1
Esophageal squamous papillomas. A: Amplified chromogenic in situ hybridization, episomal infection with diffuse nuclear staining pattern; B: Amplified chromogenic in situ hybridization, nuclear granular staining pattern; C: p53 expression; D: Ki67 expression.
See this image and copyright information in PMC

References

    1. Adler RH, Carberry DM, Ross CA. of the esophagus: association with hiatal hernia. J Thorac Surg. 1959;37:625–635. - PubMed
    1. Carr NJ, Bratthauer GL, Lichy JH, Taubenberger JK, Monihan JM, Sobin LH. Squamous cell papillomas of the esophagus: a study of 23 lesions for human papillomavirus by in situ hybridization and the polymerase chain reaction. Hum Pathol. 1994;25:536–540. - PubMed
    1. Szanto I, Szentirmay Z, Banai J, Nagy P, Gonda G, Voros A, Kiss J, Bajtai A. [Squamous papilloma of the esophagus. Clinical and pathological observations based on 172 papillomas in 155 patients] Orv Hetil. 2005;146:547–552. - PubMed
    1. Colina F, Solis JA, Munoz MT. Squamous papilloma of the esophagus. A report of three cases and review of the literature. Am J Gastroenterol. 1980;74:410–414. - PubMed
    1. Parnell SA, Peppercorn MA, Antonioli DA, Cohen MA, Joffe N. Squamous cell papilloma of the esophagus. Report of a case after peptic esophagitis and repeated bougienage with review of the literature. Gastroenterology. 1978;74:910–913. - PubMed

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