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Comment
. 2008 Dec 15;14(24):7969-70.
doi: 10.1158/1078-0432.CCR-08-2417.

Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?

Gregg L Semenza  1
Affiliations
Comment

Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?

Gregg L Semenza. Clin Cancer Res. .

Abstract

Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.

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