Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes
- PMID: 19088733
- DOI: 10.1038/ni0109-11
Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes
Abstract
New findings show that a subpopulation of mucosal ROR gammat+ cells expresses natural killer cell receptors and produces interleukin 22. These innate immune cells may be pivotal in maintaining mucosal homeostasis.
Comment on
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RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells.Nat Immunol. 2009 Jan;10(1):83-91. doi: 10.1038/ni.1684. Epub 2008 Nov 23. Nat Immunol. 2009. PMID: 19029903 Free PMC article.
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Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin.Nat Immunol. 2009 Jan;10(1):75-82. doi: 10.1038/ni.1681. Epub 2008 Nov 23. Nat Immunol. 2009. PMID: 19029904
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Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells.Nat Immunol. 2009 Jan;10(1):66-74. doi: 10.1038/ni.1668. Epub 2008 Nov 23. Nat Immunol. 2009. PMID: 19029905
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