Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Feb;116(2):161-5.
doi: 10.1007/s00702-008-0170-0. Epub 2008 Dec 17.

Dopamine transporter immunoreactivity in peripheral blood lymphocytes in multiple system atrophy

Francesca R Buttarelli  1 , Annapia Circella, Clelia Pellicano, Dorina Tiple, Morena Giovannelli, Carlo Colosimo, Francesco E Pontieri
Affiliations

Dopamine transporter immunoreactivity in peripheral blood lymphocytes in multiple system atrophy

Francesca R Buttarelli et al. J Neural Transm (Vienna). 2009 Feb.

Abstract

Previous studies showed the reduction of dopamine transporter immunoreactivity (DAT-IR) in peripheral blood lymphocytes (PBL) in Parkinson's disease. Here we report the reduction of DAT-IR in PBL in the extrapyramidal variant of multiple system atrophy. These results suggest the reduction of DAT-IR in PBL in a variety of neurodegenerative disorders, provided the presence of damage of the central dopaminergic systems. The reduction of DAT-IR in PBL in these disorders may represent a compensatory phenomenon aimed at reducing intracellular dopamine influx and, consequently, dopamine-mediated aggravation of oxidative stress in these cells.

PubMed Disclaimer

References

    1. J Auton Pharmacol. 1999 Jun;19(3):151-9 - PubMed
    1. Neurochem Res. 2008 Jun;33(6):1011-6 - PubMed
    1. Neuropharmacology. 2007 Dec;53(7):791-800 - PubMed
    1. J Neuroimmunol. 1999 May 3;96(2):234-40 - PubMed
    1. Neurology. 2006 Feb 28;66(4):529-34 - PubMed

Publication types

LinkOut - more resources