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. 2009 Jan-Feb;44(1):34-49.
doi: 10.1080/10409230802594043.

RNA under attack: cellular handling of RNA damage

Elisabeth J Wurtmann  1 , Sandra L Wolin
Affiliations

RNA under attack: cellular handling of RNA damage

Elisabeth J Wurtmann et al. Crit Rev Biochem Mol Biol. 2009 Jan-Feb.

Abstract

Damage to RNA from ultraviolet light, oxidation, chlorination, nitration, and akylation can include chemical modifications to nucleobases as well as RNA-RNA and RNA-protein crosslinking. In vitro studies have described a range of possible damage products, some of which are supported as physiologically relevant by in vivo observations in normal growth, stress conditions, or disease states. Damage to both messenger RNA and noncoding RNA may have functional consequences, and work has begun to elucidate the role of RNA turnover pathways and specific damage recognition pathways in clearing cells of these damaged RNAs.

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Figures

Fig. 1
Fig. 1
UV photoproducts. UV modification of bases can occur to free nucleobases (R = H) or in ribonucleosides, ribonucleotides, or in the context of an oligoribonucleotide (R = ribose). Figures produced with MarvinSketch (ChemAxon).
Fig. 2
Fig. 2
Chemically modified bases. R = H for free nucleobases or R = ribose for ribonucleosides.
See this image and copyright information in PMC

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