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. 2008 Dec 17:2:391.
doi: 10.1186/1752-1947-2-391.

Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report

Atsushi Nakajima  1 , Hirokazu Takahashi, Masahiko Inamori, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Shoji Yamanaka
Affiliations

Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report

Atsushi Nakajima et al. J Med Case Rep. .

Abstract

Introduction: The granulocyte-colony stimulating factor-producing tumor was first reported in 1977, however, anaplastic pleomorphic type carcinoma of the pancreas producing granulocyte-colony stimulating factor is still rare.

Case presentation: A 63-year-old man was admitted to our hospital with body weight loss (-10 kg during months) and upper abdominal pain from 3 weeks. Abdominal computed tomography demonstrated a pancreatic tumor 10 cm in size and multiple low-density areas in the liver. On admission, the peripheral leukocyte count was elevated to 91,500/mm3 and the serum concentration of granulocyte-colony stimulating factor was 134 pg/mL (normal, < 18.1 pg/mL). Based on liver biopsy findings, the tumor was classified as an anaplastic pleomorphic-type carcinoma. Immunohistochemical staining showed that pancreatic carcinoma cells were positive for granulocyte-colony stimulating factor. The patient developed interstitial pneumonia, probably caused by granulocyte-colony stimulating factor, and died 11 days after admission.

Conclusion: This is a rare case report of anaplastic pleomorphic-type carcinoma of the pancreas producing granulocyte-colony stimulating factor and confirmed by immunohistochemistry.

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Figures

Figure 1
Figure 1
Computed tomography showed an unevenly enhanced mass 10 cm in diameter in the patient's left upper abdomen.
Figure 2
Figure 2
Histopathologic diagnosis of the tumor was an anaplastic pleomorphic-type carcinoma (hematoxylin and eosin stain; ×100).
Figure 3
Figure 3
Immunohistochemical staining of formalin-fixed paraffin-embedded liver biopsy material was performed. The pancreatic cancer cells were positive for granulocyte-colony stimulating factor (×40).
See this image and copyright information in PMC

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