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Review
. 1991 Jul:26 Suppl 3:135-8.
doi: 10.1007/BF02779283.

Epidemiology of hepatitis E in China

H Zhuang  1 , X Y Cao, C B Liu, G M Wang
Affiliations
Review

Epidemiology of hepatitis E in China

H Zhuang et al. Gastroenterol Jpn. 1991 Jul.

Abstract

A total of 9 hepatitis E epidemics have been documented in China since 1982. Five of them were waterborne and four foodborne, and they occurred in 6 of 30 provinces or autonomous regions in the country. The disease most frequently affects young adults, with fewer cases in children and the elderly. A relative male excess of cases has been observed. However, the fatality rate in female patients with hepatitis E is significantly higher than in males. The disease has a distinctive autumn seasonality in endemic areas. A peak of fecal excretion of hepatitis E virus is found at the late incubation period and early acute phase. The incubation period of the disease ranges from 15 to 75 days, with a mean of 36 days. A randomized double-blind and controlled study showed that human immune serum globulin had no prophylactic effects on hepatitis E.

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