Seroepidemiology of HBV and HCV infection in Jakarta, Indonesia

Abstract

A total of 545 serum samples were consecutively collected from patients with acute hepatitis, chronic hepatitis, liver cirrhosis, hepatocellular carcinoma, chronic hemodialysis and voluntary blood donors to study the seroepidemiology of HBV and HCV infection in Jakarta. Fourteen out of 243 or 5.8% samples from blood donors were HBsAg-positive, while HCV-antibodies (anti-C100 and/or anti-CP9 and/or anti-CP10) positivity rate was found in 59 out of 243 or 24.3%. Out of 91 donors aged 29 years or younger, 15 (16.5%) donors turned positive for HCV-antibody (-ies), while out of 152 donors aged 30 years or above, 44 (28.9%) donors were anti-HCV-positive, showing a higher HCV-antibody prevalence among higher age group. Among 88 acute hepatitis patients, 33 (37.5%) cases, 10 (11.4%) cases, 15 (17.0%) cases and 30 (34.1%) cases were diagnosed as hepatitis A, hepatitis B, acute exacerbation of HCV carriers, and NANB hepatitis respectively. HCV-antibodies were found in 15 (45.5%) of hepatitis A cases and 6 (40.0%) of acute exacerbation of HBV carrier cases, but found only in 9 (30.0%) of acute NANB hepatitis cases. Positivity rates of HCV-antibodies among 23 chronic hepatitis, 80 liver cirrhosis and 64 hepatocellular carcinoma cases were 78.3%, 75.0% and 65.6% respectively, while 30.4%, 30.0% and 45.3% of the respective groups were positive for HBs antigen. Among 47 hemodialysis cases, 97.9% and 6.4% were positive for HCV antibodies and HBs antigen respectively. It was concluded that: (1) HBV infection rate is high among blood donors and patients with acute and chronic liver diseases. (2) HCV infection rate is high among blood donors.(ABSTRACT TRUNCATED AT 250 WORDS)