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Review
. 2009 Mar;5(1):61-5.
doi: 10.1007/s12015-008-9048-7. Epub 2008 Dec 18.

Cancer stem cells: lessons from melanoma

Caterina La Porta  1
Affiliations
Review

Cancer stem cells: lessons from melanoma

Caterina La Porta. Stem Cell Rev Rep. 2009 Mar.

Abstract

The model of cancer stem cells in tumor development states that tumors contain a subset of cells that both self renew and give rise to differentiated progeny. Like normal adult tissue stem cells, cancer stem cells are a minority of the whole tumor and are the only cells that are able to maintain tumor growth indefinitely. In the present review is critically discussed the actually existence of a cancer stem cell subpopulation in melanoma. The self-renewal signaling pathways as well as specific markers like as CD133, ABCB5 and ABCG2 recently identified in putative melanoma cancer stem cells are also discussed.

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