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. 2009 Jan;11(1):59-65.
doi: 10.1007/s11908-009-0009-3.

Monitoring antimalarial drug efficacy: current challenges

Miriam K Laufer  1
Affiliations

Monitoring antimalarial drug efficacy: current challenges

Miriam K Laufer. Curr Infect Dis Rep. 2009 Jan.

Abstract

Access to effective antimalarial therapy has increased dramatically. As malaria-endemic countries begin to use artemisinin-based combination therapy (ACT) to treat malaria, detecting the emergence and spread of resistance has become more complicated but also more urgent. Clinical efficacy studies may not be sensitive enough to detect the failure of a single component of combination therapy while standardized criteria for in vitro resistance and validated molecular markers are not yet available to many currently deployed drugs. This review discusses the challenges to various methods to monitor antimalarial drug resistance and proposes an integrated approach to the rapid detection and characterization of resistance to ACTs should it arise.

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Figures

Figure 1
Figure 1
A proposed algorithm to investigate suspected outbreaks of resistance to artemisinin-based combination therapy (ACT). (From Laufer et al. [17•], with permission.)
See this image and copyright information in PMC

References

    1. World Health Organization . Assessment and Monitoring of Antimalarial Drug Efficacy for the Treatment of Uncomplicated Falciparum Malaria. World Health Organization; Geneva, Switzerland: 2003.
    1. Stepniewska K, Taylor WR, Mayxay M, et al. In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. Antimicrob Agents Chemother. 2004;48:4271–4280. - PMC - PubMed
    1. World Health Organization . Methods and Techniques for Clinical Trials on Antimalarial Drug Efficacy: Genotyping to Identify Parasite Populations. World Health Organization; Geneva, Switzerland: 2008.
    1. Hoffman SL, Masbar S, Hussein PR, et al. Absence of malaria mortality in villagers with chloroquine-resistant Plasmodium falciparum treated with chloroquine. Trans R Soc Trop Med Hyg. 1984;78:175–178. - PubMed
    1. Djimde AA, Doumbo OK, Traore O, et al. Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria. Am J Trop Med Hyg. 2003;69:558–563. - PubMed