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. 2009 Mar;42(4-5):426-9.
doi: 10.1016/j.clinbiochem.2008.11.008. Epub 2008 Dec 3.

Identifying novel autoantibody signatures in ovarian cancer using high-density protein microarrays

C Geeth Gunawardana  1 , Nader Memari, Eleftherios P Diamandis
Affiliations

Identifying novel autoantibody signatures in ovarian cancer using high-density protein microarrays

C Geeth Gunawardana et al. Clin Biochem. 2009 Mar.

Abstract

Objectives: To identify autoantibody signatures in ovarian cancer using protein microarray technology.

Design and methods: Protein microarrays were screened using non-malignant peritoneal fluid (n=30) and ascites fluid pooled from ovarian cancer patients (n=30).

Results: Fifteen potential tumour-associated antigens were discovered. AASDHPPT showed the strongest signal-to-noise ratio.

Conclusions: Protein microarrays are suitable for autoantibody discovery in ovarian cancer but the signatures are of low frequency.

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