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Review
. 2009 Apr;50 Suppl(Suppl):S423-8.
doi: 10.1194/jlr.R800094-JLR200. Epub 2008 Dec 17.

Prostanoids in health and disease

Emer M Smyth  1 , Tilo Grosser, Miao Wang, Ying Yu, Garret A FitzGerald
Affiliations
Review

Prostanoids in health and disease

Emer M Smyth et al. J Lipid Res. 2009 Apr.

Abstract

The prostanoids are a family of lipid mediators generated by the action of cyclooxygenase on a 20-carbon unsaturated fatty acid, arachidonic acid. Prostanoids are generated widely in response to diverse stimuli and, acting in a paracrine or autocrine manner, play important roles in normal physiology and disease. This review summarizes the current knowledge on prostanoid generation and the roles of individual mediators, their biosynthetic pathways, and their receptors in health and disease.

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Figures

Fig. 1.
Fig. 1.
The prostanoid biosynthesis response pathway.
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