Aquaporins in secretory glands and their role in Sjögren's syndrome

Abstract

Salivary, lacrimal and pancreatic secretions are known to account for multiple physiological functions. These exocrine secretions are watery fluids containing electrolytes, and a mixture of proteins, and can be stimulated by a number of agonists. Since water movement is involved in exocrine secretion, aquaporins (AQPs) have been hypothesised to contribute to fluid production in exocrine glands. This chapter will focus on the expression, localisation and function of AQPs in salivary and lacrimal glands and pancreas. The role of multiple water and ion transporters and channels in exocrine fluid secretion will also be reviewed. Finally, this chapter will address the potential role of AQPs in Sjögren's syndrome.