Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Feb;5(1):67-72.
doi: 10.1007/s11420-008-9103-6. Epub 2008 Dec 19.

Catastrophic antiphospholipid syndrome triggered by sepsis

Susan Kim  1 , Neal K Moskowitz, Edward F DiCarlo, Anne R Bass, Doruk Erkan, Michael D Lockshin
Affiliations

Catastrophic antiphospholipid syndrome triggered by sepsis

Susan Kim et al. HSS J. 2009 Feb.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Computed tomography angiography of right hand. Open arrows showing intact but diminished perfusion of distal radial and ulnar arteries, day 4 of hospitalization
Fig. 2
Fig. 2
Platelet trend during hospitalization (initial 7 days)
Fig. 3
Fig. 3
Amputated hand specimen in low-power photomicrograph showing thrombosis of the two veins (open arrows) accompanying a medium-sized muscular artery (closed arrow) that is patent (×4, H&E)
Fig. 4
Fig. 4
Amputated hand specimen in intermediate power photomicrograph of a small muscular artery (closed arrow) showing recent occlusion by a fibrin clot (open arrow) without inflammation of the vessel wall but with hematoma (open circle) in the surrounding tissue (×20, H&E)
Fig. 5
Fig. 5
Amputated hand specimen in intermediate-power photomicrograph of two dermal veins (arrows) showing endothelial organization and recanalization of fibrin thrombi (open circles; ×20, H&E)
Fig. 6
Fig. 6
Amputated hand specimen in high-power photomicrograph of necrotic skeletal muscle showing interstitial edema (arrow heads) and patency of the capillary network (open arrow; ×40, H&E)
See this image and copyright information in PMC

References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1191/0961203303lu394oa', 'is_inner': False, 'url': 'https://doi.org/10.1191/0961203303lu394oa'}, {'type': 'PubMed', 'value': '12892393', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12892393/'}]}
    2. Asherson RA, Cervera R, de Groot PG et al (2003) Catastrophic Antiphospholipid Syndrome Registry Project Group. Catastrosphic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines. Lupus 12:530–534 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1161/hh0102.102795', 'is_inner': False, 'url': 'https://doi.org/10.1161/hh0102.102795'}, {'type': 'PubMed', 'value': '11786515', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11786515/'}]}
    2. Rand JH (2002) Molecular pathogenesis of antiphospholipid syndrome. Circ Res 90:29–37 - PubMed
    1. Cervera R, Asherson RA (2006) Catastrophic antiphospholipid syndrome. J Pathophy Haem Thrombosis 181–186 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1093/rheumatology/41.8.924', 'is_inner': False, 'url': 'https://doi.org/10.1093/rheumatology/41.8.924'}, {'type': 'PubMed', 'value': '12154210', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12154210/'}]}
    2. Erkan D, Yazici Y, Peterson MG et al (2002) A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome. Rheumatology 41:924–929 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1177/0885066606287041', 'is_inner': False, 'url': 'https://doi.org/10.1177/0885066606287041'}, {'type': 'PubMed', 'value': '16672637', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/16672637/'}]}
    2. Vero SK, Asherson RA, Erkan D (2006) Catastrophic antiphospholipid syndrome. J Intensive Care Med 21:144–159 - PubMed

Publication types