Review
doi: 10.1097/PAP.0b013e3181915e94.
D2-40 immunohistochemistry--so far!
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- PMID: 19098468
- DOI: 10.1097/PAP.0b013e3181915e94
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Review
D2-40 immunohistochemistry--so far!
Adv Anat Pathol.
2009 Jan.
Abstract
D2-40 is a commercially available monoclonal antibody directed against human podoplanin, a transmembrane mucoprotein that is expressed in lymphatic endothelial cells. Since its introduction, D2-40 immunoexpression has been described in a variety of lymphovascular neoplasms including lymphangioma, Kaposi sarcoma, and hemangioendothelioma, as well as nonvascular neoplasms such as epithelioid mesothelioma, seminoma, and hemangioblastoma. More recently, D2-40 immunoexpression has been reported in primary adrenal cortical tumors, schwannomas, and adnexal tumors of the skin. This brief review provides an update on the ever-expanding proposed applications of D2-40 immunohistochemistry in surgical pathology.
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