Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Aug;82(8):934-41.
doi: 10.1111/j.1349-7006.1991.tb01924.x.

Abnormal expression of blood group-related antigens in uterine endometrial cancers

K Tsukazaki  1 , M Sakayori, H Arai, K Yamaoka, S Kurihara, S Nozawa
Affiliations

Abnormal expression of blood group-related antigens in uterine endometrial cancers

K Tsukazaki et al. Jpn J Cancer Res. 1991 Aug.

Abstract

The expression of A, B, and H group antigens, Lewis group antigens (Lewis(a), Lewis(b), Lewis(x), and Lewis(y)), and Lc4 and nLc4 antigens, the precursor antigens of both groups, was examined immunohistochemically with monoclonal antibodies in 9 normal endometria, 6 endometrial hyperplasias, and 31 endometrial cancers. 1) A, B and/or H antigens were detected in endometrial cancers at an incidence of 51.6%, while no distinct localization of these antigens was observed in normal endometria. H antigen, the precursor of A and B antigens, was particularly frequently detected in endometrial cancers. 2) An increased rate of expression of Lewis group antigens, particularly Lewis(b) antigen, was observed in endometrial cancers compared with its expression in normal endometria. 3) Lc4 and nLc4 antigens were detected in endometrial cancers at rates of 41.9% and 38.7%, respectively, these expressions being increased compared with those in normal endometria. 4) These results suggest that a highly abnormal expression of blood group-related antigens in endometrial cancers occurs not only at the level of A, B, and H antigens and Lewis group antigens, but also at the level of their precursor Lc4 and nLc4 antigens. 5) Lewis(a), Lewis(b), and Lc4 antigens, built on the type-1 chain, are more specific to endometrial cancers than their respective positional isomers, Lewis(x), Lewis(y), and nLc4 antigens, built on the type-2 chain.

PubMed Disclaimer

References

    1. ) Nozawa , S. , Sakayori , M. , Ohta , K. , Lizuka , R. , Mochizuki , H. , Soma , M. , Fujimoto , J. , Hata , J. , Iwamori , M. and Nagai , Y.A monoclonal antibody (MSN‐1) against a newly established uterine endometrial cancer cell line (SNG‐II) and its application to immunohistochemistry and flow cytometry . Am. J. Obstet. Gynecol , 161 , 1079 – 1086 ( 1981. ). - PubMed
    1. ) Feizi , T.Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are oncodevelopmental antigens . Nature , 314 , 53 – 57 ( 1985. ). - PubMed
    1. ) Kavarik , S. , Davidsohn , I. and Stejkal , R.ABO antigens in cancer . Arch. Pathol , 86 , 12 – 21 ( 1968. ). - PubMed
    1. ) Magnani , J. L. , Nilsson , B. , Brockhaus , M. , Zopt , D. , Steplewski , Z. , Koprowski , H. and Ginsburg , V.A monoclonal antibody defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lactoN‐fucopentaoseII . J. Biol. Chem. , 257 , 14365 – 14369 ( 1982. ). - PubMed
    1. ) Hakomori , S.Tumor associated carbohydrate antigens . Ann. Rev. Immunol , 2 , 103 – 126 ( 1984. ). - PubMed

LinkOut - more resources