Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Dec 19;29(6):835-8.
doi: 10.1016/j.immuni.2008.12.003.

A prescription for human immunology

Mark M Davis  1
Affiliations

A prescription for human immunology

Mark M Davis. Immunity. .

Abstract

Inbred mice have been an extremely successful tool for basic immunology, but much less so as models of disease. Thus, to maximize the use of immunologic approaches to improve human health, we need more strategically directed efforts in human immunology. This would also open up new opportunities for basic research.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Representative Assay for a Particular White Blood Cell
Here a given white blood cell is assayed for either a function or an array of biomarkers in both normal and diseased/aged individuals such that a range from overactive to underactive properties is registered. For the major cell types, it is likely that a deficiency in any one of them will disable the entire system in some way.
See this image and copyright information in PMC

References

    1. Allantaz F, Chaussabel D, Banchereau J, Pascual V. Microarray-based identification of novel biomarkers in IL-1-mediated diseases. Curr Opin Immunol. 2007;19:623–632. - PMC - PubMed
    1. Chaussabel D, Quinn C, Shen J, Patel P, Glaser C, Baldwin N, Stichweh D, Blankenship D, Li L, Munagala I, et al. A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. Immunity. 2008;29:150–164. - PMC - PubMed
    1. Cohen AC, Nadeau KC, Tu W, Hwa V, Dionis K, Bezrodnik L, Teper A, Gaillard M, Heinrich J, Krensky AM, et al. Decreased accumulation and regulatory function of CD4+CD25high T cells in human STAT5b deficiency. J Immunol. 2006;177:2770–2774. - PubMed
    1. Collins FS, Morgan M, Patrinos A. The Human Genome Project: Lessons from Large-Scale Biology. Science. 2003;300:286–290. - PubMed
    1. Hayday AC, Peakman M. The habitual, diverse and surmountable obstacles to human immunology research. Nat Immunol. 2008;9:575–580. - PubMed

Publication types

Substances