CD44 keeps tumor killers polarized
- PMID: 19100697
- DOI: 10.1016/j.immuni.2008.12.004
CD44 keeps tumor killers polarized
Abstract
In this issue of Immunity, Mrass et al. (2008) report that CD44 critically contributes to the stabilization of polarity in migrating cytotoxic T lymphocytes by anchoring cytoskeletal proteins to the cell membrane at their uropods.
Comment on
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CD44 mediates successful interstitial navigation by killer T cells and enables efficient antitumor immunity.Immunity. 2008 Dec 19;29(6):971-85. doi: 10.1016/j.immuni.2008.10.015. Immunity. 2008. PMID: 19100702 Free PMC article.
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