Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Dec 19;29(6):845-7.
doi: 10.1016/j.immuni.2008.12.002.

Elite suppression of HIV-1 replication

Joel N Blankson  1 , Robert F Siliciano
Affiliations
Free article
Comment

Elite suppression of HIV-1 replication

Joel N Blankson et al. Immunity. .
Free article

Abstract

Rare HIV-1-infected individuals are able to control viral replication without antiretroviral therapy. In this issue of Immunity, Migueles et al. (2008) show that HIV-1-specific CD8+ T cells from these individuals effectively suppress viral replication by granzyme B-mediated killing of target cells.

PubMed Disclaimer

Comment on

  • Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.
    Migueles SA, Osborne CM, Royce C, Compton AA, Joshi RP, Weeks KA, Rood JE, Berkley AM, Sacha JB, Cogliano-Shutta NA, Lloyd M, Roby G, Kwan R, McLaughlin M, Stallings S, Rehm C, O'Shea MA, Mican J, Packard BZ, Komoriya A, Palmer S, Wiegand AP, Maldarelli F, Coffin JM, Mellors JW, Hallahan CW, Follman DA, Connors M. Migueles SA, et al. Immunity. 2008 Dec 19;29(6):1009-21. doi: 10.1016/j.immuni.2008.10.010. Epub 2008 Dec 8. Immunity. 2008. PMID: 19062316 Free PMC article.

MeSH terms

Substances