Centrifugal modulation of human LEP components to a task-relevant noxious stimulation triggering voluntary movement

Abstract

In the present study, we investigate the top-down centrifugal modulation of neural responses to a task-relevant noxious stimulation triggering voluntary movement by recording magnetoencephalography (MEG) and electroencephalography (EEG) simultaneously. An auditory warning signal was followed 2-3 s later by a noxious YAG laser stimulation as an imperative signal delivered to the left hand dorsum. Ten normal subjects performed three different conditions, Control, Movement, and Count. In Control, the subjects were asked to relax and rest quietly with no task. In Movement, the subjects extended the left index finger after imperative stimuli. In Count, the subjects counted the number of imperative stimuli silently. The amplitude of the N2 component recorded by EEG, which peaked about 220 ms after noxious stimulation, was significantly attenuated in Movement, but not in Count, compared to Control. The root-mean-square (RMS) from both hemispheres, and areal mean signal (AMS) amplitudes and the equivalent current dipole (ECD) strengths from SI/PPC and bilateral SII recorded at around 170 ms by MEG were not significantly different among the three conditions. In contrast, ECD strengths and AMS amplitudes from the anterior cingulate cortex (ACC), which showed a similar peak to the N2 component, were smaller in Movement than Control and Count. We therefore suspect that neural activities related to generator mechanisms of N2, especially including ACC, are inhibited by movement-related neural activities during the preparatory period. The present findings indicate a characteristic of pain-motor integration in a movement preparatory period.