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. 2009 Apr;52(4):497-502.
doi: 10.1002/pbc.21835.

Potential chemotherapy side effects: what do oncologists tell parents?

Lisa Ysela Ramirez  1 , Samantha E Huestis, Tsiao Yi Yap, Stephen Zyzanski, Dennis Drotar, Eric Kodish
Affiliations

Potential chemotherapy side effects: what do oncologists tell parents?

Lisa Ysela Ramirez et al. Pediatr Blood Cancer. 2009 Apr.

Abstract

Background: In order to determine the number of short-term side effects and late effects discussed during an informed consent conference (ICC) after the diagnosis of acute leukemia, we observed the occurrence(s) and the ratio between short-term side effects versus late effects during an ICC.

Procedure: ICC(s) of childhood leukemia trials were audio-taped at six different study sites. The side effects mentioned during each of these ICC(s) were coded and analyzed.

Results: One hundred forty cases were reviewed, from which we coded a total of 3,173 acute side effects and 242 late effects. The mean total side effects mentioned during each ICC was 24 (range 5-47). The number of late effects coded were significantly less than acute side effects. We also found that the duration of ICC(s) was positively correlated with the number of side effects mentioned. In addition, the frequency of total side effects mentioned was independent of patient or parent demographic factors.

Conclusions: Our results show that acute side effects are often mentioned but the discussion of late effects is much less frequent in the initial ICC(s). Careful consideration regarding the ratio of acute and late effects that are communicated to parents in the context of the ICC may facilitate parental understanding of clinically relevant side effects.

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References

    1. Alvarez JA, Scully RE, Miller TL, Armstrong FD, Constine LS, Friedman DL, et al. Long-term effects of treatments for childhood cancers Curr Opin Pediatr 2007. Feb; 19123–31. - PubMed
    1. Greenberg LW, Jewett LS, Gluck RS, Champion LA, Leikin SL, Altieri MF, et al. Giving information for a life-threatening diagnosis. parents’ and oncologists’ perceptions Am J Dis Child 1984. Jul;1387649–53. - PubMed
    1. Dixon-Woods M, Findlay M, Young B, Cox H, Heney D.Parents’ accounts of obtaining a diagnosis of childhood cancer Lancet 2001. Mar 3;3579257670–4. - PubMed
    1. Eiser C, Parkyn T, Havermans T, McNinch A. Parents’ recall on the diagnosis of cancer in their child. Psycho onc. 1994;3:197–203.
    1. Nitschke R, Olson R, Kaufman K, Funk M. Medical staff’s communication skills with family mebers of children with cancer. Proceedings of ASCO. 1986;5(March):243.

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